Played a neurotic wife in "The Anniversary Party"
Played a woman divorcing her rock star husband (Michael Sheen) in the romantic comedy "The Laws of Attraction"
Played ruthless villain Danica Talos in "Blade: Trinity"
Starred as an assistant D.A. uncovering an AIDS-related mystery in "The Event"
Teamed up with Amy Poehler and Rachel Dratch in the comedy feature "Spring Breakdown"
Played supporting role opposite Cameron Diaz in "The Sweetest Thing"
Played a single mom thrown into a world of international espionage in "Fay Grim," Hal Hartley's sequel to his 1997 film "Henry Fool"
Cast as Kitty Koslowski, Lex Luthor's villainous henchwoman in Bryan Singer's "Superman Returns"
Co-starred with Jessica Alba in the supernatural thriller "The Eye"
Gave memorable comedic performance in "Scream 3"
Raised in Monroe, LA and Laurel, MS
Appeared in teen flick "Josie and the Pussycats"
Guest starred on Showtime's "The Big C" and the CBS drama "The Good Wife"
Portrayed Hemingway's fourth wife Mary in the HBO film "Hemingway & Gellhorn"
Cast as Louis C.K.'s girlfriend on FX comedy "Louie"
Appeared in critically acclaimed feature "Henry Fool"; film won Best Screenwriting Award at Cannes
Made Broadway debut opposite Matthew Broderick in the Elaine May comedy "Taller Than a Dwarf"
Feature acting debut, "Joey Braker"; also appeared in "Coneheads" and "Dazed and Confused"
Starred in the Independent feature "The Event"
Starred in Zoe Cassavetes' directorial debut "Broken English"; earned an Independent Spirit Award Nomination for Best Actress
Cast in first major feature role supporting Tom Hanks and Meg Ryan in "You've Got Mail"
Featured in Christopher Guest's award-winning comedy "Best in Show"
Reunited with director Christopher Guest to play an actress in "For Your Consideration"
Starred in the award-winning independent film "The Daytrippers" (premiered at Toronto Film Festival)
TV miniseries debut, "Armistead Maupin's Tales of the City" (PBS)
Co-starred in "Hell on Heels: The Battle of Mary Kay"; received a Golden Globe nomination for Best Supporting Actress
Earned acclaim for performance as Jackie-O, a mentally unbalanced woman who thinks she's Jackie Kennedy in "The House of Yes"
Made TV debut in a regular role on "As the World Turns" (CBS)
Co-starred with Kyra Sedgwick and Fairuza Balk in Rebecca Miller's "Personal Velocity"; earned an Independent Spirit Award Nomination for Best Actress
Appeared in lead role in the film "Party Girl"
Co-starred in workplace comedy "Clockwatchers" with Lisa Kudrow and Toni Collette
Appeared in "Waiting for Guffman"
Appeared in series regular role on "Lost in Space"
Published memoir <i>You're On An Airplane</i>