Acted the part of Vicki Weaver in "Ruby Ridge: An American Tragedy" (CBS)
Appeared in the drama "The Prize Winner of Defiance Ohio" opposite Julianne Moore
Offered a critically acclaimed performance in Showtime's "The Baby Dance"; produced by Jodie Foster; earned a Golden Globe nomination
Played Molly Shannon's know-it-all sister-in-law in "Year of the Dog"
Portrayed a criminologist assisting in the tracking of a pair of escaped convicts in the Clint Eastwood-directed "A Perfect World"
Portrayed controversial Florida politician Katherine Harris in the HBO movie "Recount"; earned Emmy and SAG nominations for Best Actress in a TV-Movie
Reteamed with Lynch to star in "Inland Empire"
Acted with then-boyfriend Billy Bob Thornton in "Daddy and Them"; written and directed by Thornton
Played bit part as an irksome party crasher in Adrian Lyne's "Foxes"
Reteamed with Stoltz for the forced and disappointing "Haunted Summer"
Starred as a pure-hearted nymphomaniac in Martha Coolidge's "Rambling Rose"; earned first Best Actress Academy Award nomination; also earned a Golden Globe nomination
Cast as a doctor who takes on HMOs in the Showtime movie "Damaged Care"
Executive produced (and acted in) Showtime's "Down Came a Blackbird"
Played a young student opposite Nick Nolte in "Teachers"
Received an Emmy nomination for her performance as the widow of an Air Force pilot in the HBO film "Afterburn"
Cast as a woman who falls in love with a man who may be a murderer on the Showtime series "Fallen Angels"; received an Emmy nomination
Co-starred in "Happy Endings," a comedic drama about the ups and downs of relationships
Made a brief appearance in Martin Scorsese's "Alice Doesn't Live Here Anymore"
Offered an impressive performance as a sexually curious teenager in her first leading role in Joyce Chopra's "Smooth Talk"
Portrayed an irresponsible and drug abusing pregnant woman in Alexander Payne's directorial debut "Citizen Ruth"; Diane Ladd makes a cameo appearance as Dern's mother
Joined the ensemble cast of "Little Fockers," opposite Ben Stiller, Robert De Niro, and Dustin Hoffman
Starred on HBO's "Enlightened" as a corporate executive who winds up in a mental health treatment center after a nervous breakdown
Guest starred on "The Last Man on Earth"
Played a chain-smoking floozy in Lynch's "Wild at Heart"; onscreen mom played by her real-life mother Diane Ladd
Attracted attention as Eric Stoltz's blind girlfriend in Peter Bogdanovich's "Mask"
Cast as a paleontologist in Steven Spielberg's blockbuster feature "Jurassic Park"
Made TV debut on the CBS soap opera "The Secret Storm"; her mother played a regular on the series
Played a teacher opposite Jake Gyllenhaal and Chris Cooper in Joe Johnston's "October Sky"
Received an Emmy nomination for her guest role as a lesbian who coaxes Ellen DeGeneres out of the closet in the famous "Puppy Episode" of the ABC series "Ellen"
Made TV-movie debut in "Happy Endings"
Co-starred with Mark Ruffalo, Peter Krause and Naomi Watts in "We Don't Live Here Anymore"
Made directorial debut with "The Gift"; also starred with Diane Ladd and Isabella Rossellini; broadcast as a presentation of Showtime's Directed By series
First collaboration with director David Lynch in "Blue Velvet"
Had first feature film credit as an extra in "White Lightning"
Made New York stage debut opposite then-boyfriend Kyle MacLachlan in the off-Broadway production "The Palace of Amateurs"
Appeared in Paul Thomas Anderson's "The Master"
Co-starred in film adaptation of Cheryl Strayed memoir "Wild"
Received her second Oscar nomination for "Wild"
Co-starred in "F is for Family"
Co-starred in the hotly anticipated drama "Certain Women"
Co-starred alongside Michael Keaton in McDonald's founder biopic "The Founder"
Co-starred on HBO drama "Big Little Lies"
Appeared as Diane, Dale Cooper's secretary, on the third season of "Twin Peaks"
Cast as Vice Admiral Amilyn Holdo "Star Wars: The Last Jedi"