Co-starred with Ashton Kutcher in romantic comedy "What Happens in Vegas..."
Starred opposite Ewan McGregor in Danny Boyle's "A Life Less Ordinary"
Reunited with Tom Cruise in the action/comedy "Knight and Day," about a fugitive couple on a glamorous and deadly adventure across the globe
Appeared in the ensemble of "The Last Supper"
Co-starred with Jude Law in director Nancy Meyers' romantic comedy "The Holiday"
Landed leading role opposite Harvey Keitel in "Head Above Water"; premiered on HBO before receiving a theatrical release
Once again voiced Princess Fiona in "Shrek Forever After"
Reprised role in "Charlie's Angels: Full Throttle"
Co-starred with James Marsden in "The Box"
Co-starred with Toni Collette in the film "In Her Shoes"; based on the book of the same name by Jennifer Weiner
Reprised role of Princess Fiona for "Shrek the Third"
Starred in the romantic comedy "The Sweetest Thing"
Cast as Lenore, the assistant to Seth Rogen's "The Green Hornet"
Cast as one of the leads in ensemble romantic comedy "What to Expect When You're Expecting"
Played Hannigan in the "Annie" remake
Co-starred as the dumpy wife of a puppeteer in the Spike Jonze directed "Being John Malkovich"
Made her feature acting debut in "The Mask"
Featured in the ensemble comedy-drama "Things You Can Tell Just by Looking at Her"
Played a tough career woman in the Edward Burns-directed "She's the One"
Received a star on the Hollywood Walk of Fame
Began modeling at age 16; signed to the Elite Modeling Agency
Headlined the surprise hit comedy "There's Something About Mary," directed by the Farrelly brothers
Voiced the character of Princess Fiona in the hit animated film "Shrek"
Joined Drew Barrymore and Lucy Liu to star in the big screen version of "Charlie's Angels"
Played Leonardo DiCaprio's love interest in Martin Scorsese's epic "Gangs of New York"; earned a Golden Globe nomination for Best Supporting Actress
Played the mother of a cancer stricken child in "My Sister's Keeper," a Nick Cassavetes-directed adaptation of the Jodi Picoult novel
Portrayed the spurned lover of a wealthy playboy (Tom Cruise) in Cameron Crowe's "Vanilla Sky"
Co-starred with Julia Roberts and Dermot Mulroney in "My Best Friend's Wedding"
Portrayed the new owner of a struggling football franchise in Oliver Stone's "Any Given Sunday"
Returned to voice the character of Princess Fiona in "Shrek 2"
Co-starred with Justin Timberlake and Jason Segel in the comedy "Bad Teacher"
Published the book <i>The Longevity Book: The Science of Aging, the Biology of Strength, and the Privilege of Time</i>