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Voice-over narration, spoken by Bing Crosby as his character "Bill Wainwright," is heard intermittently throughout the film. According to reviews and news items, much of the film was shot on location in France, including Paris. Iphigenie Castiglioni and Albert Godderis are listed in Hollywood Reporter news items as cast members, but their appearance in the final film has not been confirmed. During filming in France, Crosby's wife Dixie died of cancer and, according to modern sources, after returning to Hollywood to shoot interior scenes, the production shut down for a two-week mourning period. Modern sources also note that while filming at the French orphanage, producer William Perlberg dressed the child actors in the clothes of the orphans and then bought new clothes for the orphans. He also asked Paramount to donate money budgeted for the production's "wrap party" to the orphanage.
Little Boy Lost marked child actor Christian Fourcade's only American film. He made his screen debut in a 1952 French release. Critics uniformally praised the eight-year-old's performance. The New York Times reviewer gushed that Fourcade "has the eyes, the expression and the voice that would tear the heart out of a heathen idol." Fourcade's mother Christiane was cast as a maid in the film, and according to modern sources, Perlberg cast his father as a barker. The film also marked cinematographer George Barnes' last production. He died on May 30, 1953. According to the New York Times review, the New York opening of the picture was a benefit for the Overseas Press Club of America. Although the Variety review mentioned a television version of Marghanita Laski's novel, "seen only a season or two back," no information about an earlier adaptation has been located. On May 1955, Dick Powell and Gladys Holland appeared in a Lux Radio Theatre version of the story, and on March 15, 1956, Dennis O'Keefe and Carl Esmond starred in a Lux Video Theatre version.